Gene expression can be monitored in living organisms with ultra-sensitive imaging systems.

BERTHOLD TECHNOLOGIES GmbH contributed a major  breakthrough of this technology with its Luminograph LB980 introduced in 1989.
Today, the next generation of low-light imagers is available, with the NightOWL II LB983, and the new NightSHADE LB985 Imaging System for plant research that has been specially designed for in-vivo plant imaging.

As the NightOWL is the first imaging instrument, where the camera is moved inside the cabinet, a lot of special applications can be easily achieved such as close-up imaging, or animal imaging in specific animal beds for multimodal imaging. Orthogonal 3D-imaging for approximate volume calculation is available.

Additionally NightOWL II offers quantitative fluorescence because the unique optical system from the Mithras multimode reader has been integrated. Based on the experiences with the NightOWL in-vivo imager Berthold Technologies has developed the new NightSHADE imaging system with plant research in mind.

Some techniques for generating and/or detecting light in biological subjects are patented and may require licences from third parties. Users are advised to independently determine for themselves wheter their activities infringe any valid patent.

Click in any of the boxes below to access details of each in-vivo imaging instrument from the BERTHOLD TECHNOLOGIES GmbH web site.